Progress on matrix metalloproteinase in axonal regeneration / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 95-100, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-255227
ABSTRACT
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases. MMPs can degrade and remodel extracellular matrix, also active or inactive many molecules attaching to matrix including receptors, growth factors and cytokines, so that injury-induced MMPs can change the extracellular environment to affect the axonal regeneration in central nervous system. In this review, with spinal cord injury (SCI) as an example we discuss the effects of MMPs on inflammation, neuronal viability, extracellular molecules, glial scar and axonal remyelination, which are all important to axonal regeneration.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Traumatismos da Medula Espinal
/
Axônios
/
Neuroglia
/
Cicatriz
/
Metaloproteinases da Matriz
/
Matriz Extracelular
/
Regeneração Nervosa
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2015
Tipo de documento:
Artigo
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