Effect of perioperative continuous epidural morphine administration on plasma D-dimer in patients undergoing total hip replacement / 南方医科大学学报
Journal of Southern Medical University
;
(12): 523-525, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-255264
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of perioperative continuous epidural morphine administration on plasma D-dimer level in patients undergoing total hip replacement.</p><p><b>METHODS</b>Forty ASA I-II patients undergoing total hip replacement under epidural anesthesia were randomized into two groups. In one group, the patients were given epidural administration of morphine 15 min before operation at 4 mg (in 10 ml normal saline) and for 48 h after the operation at 80 microg/h, while those in the other group received epidural injection of the same amount of normal saline before operation and 0.15% ropivacaine 2.0 ml/h for 48 h in the same manner after operation. Blood samples were taken before anesthesia (T(0)), at the end of operation (T(1)), and 24 h and 48 h after operation (T(2) and T(3)) for determination of plasma IL-6 and D-dimer levels.</p><p><b>RESULTS</b>In both groups plasma IL-6 and D-dimer levels showed significant increase at T(1), T(2) and T(3) in comparison with those at T(0), and their levels were significantly lower in morphine group than in ropivacaine group at T(1), T(2) and T(3).</p><p><b>CONCLUSION</b>Epidural morphine can lower plasma IL-6 and D-dimer levels and correct blood hypercoagulability in patients undergoing total hip replacement.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Período Pós-Operatório
/
Sangue
/
Injeções Epidurais
/
Produtos de Degradação da Fibrina e do Fibrinogênio
/
Interleucina-6
/
Assistência Perioperatória
/
Artroplastia de Quadril
/
Metabolismo
/
Morfina
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2006
Tipo de documento:
Artigo
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