Morphological changes of ECV304 cells infected by herpes simplex virus type 2 / 南方医科大学学报
Journal of Southern Medical University
;
(12): 445-447, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-255289
ABSTRACT
<p><b>OBJECTIVE</b>To observe the pathological changes and morphological alterations of ECV304 cells after the infection by herpes simplex virus type 2 (HSV-2) in vitro.</p><p><b>METHODS</b>Passaged ECV304 cells were infected with HSV-2, TCID50 and morphological changes were observed by optical microscopy and tissue staining.</p><p><b>RESULTS</b>One day after HSV-2 infection, swelling, rounding, and increase of thickened cytoplasmic granules occurred in the ECV304 cells, and on day 2, cell fusion was observed with weakened nuclear staining.</p><p><b>CONCLUSION</b>ECV304 cells mostly undergo necrosis after HSV-2 infection without obvious evidence of cell apoptosis.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Veias Umbilicais
/
Virologia
/
Endotélio Vascular
/
Células Cultivadas
/
Herpesvirus Humano 2
/
Infecções por Herpesviridae
/
Necrose
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2006
Tipo de documento:
Artigo
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