Effect of S-bioallethrin on human lymphocyte / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To study the effect of the S-bioallethrin on human lymphocytes by microarray technique.</p><p><b>METHODS</b>The changes of normal human lymphocytes treated with S-bioallethrin were examined with light microscope, flow cytometry, electron microscope, DNA ladder and microarray techniques.</p><p><b>RESULTS</b>Morphological study showed that the lymphocytes underwent apoptosis after S-bioallethrin exposure, which as further confirmed by the expression changes of 346 genes.</p><p><b>CONCLUSION</b>S-bioallethrin can induce apoptosis of normal human lymphocytes and changes in their gene expression profiles.</p>