Relationship between mitochondrial DNA instability and interleukin-8 activity in gastric mucosa / 中华病理学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the relationship between mitochondrial DNA instability (mtMSI) and interleukin-8 (IL-8) activity in gastric mucosa of various lesions.</p><p><b>METHODS</b>IL-8 level in gastric mucosa was assayed using ELISA method. The mtMSI was detected by PCR-SSCP techniques.</p><p><b>RESULTS</b>mtMSI was observed in 11 out of 30 (36.7%) gastric cancers, 2 of 15 (13.3%) intestinal metaplasia, 2 of 10 dysplasia and 1 of 10 chronic atrophic gastritis. IL-8 level in mtMSI+ group [(76.8 +/- 3.8) pg/mg] was significantly higher than that in mtMSI- group [(48.3 +/- 3.6) pg/mg, P < 0.05].</p><p><b>CONCLUSION</b>mtMSI closely correlates with IL-8 level in gastric mucosa and is involved in gastric carcinogenesis.</p>