Primitive study of the cell lineage and Epstein-Barr virus infection in so called malignant histiocytosis with tissue microarray technique / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 497-501, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-255381
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the cell lineage and Epstein-Barr virus infection in previously diagnosed cases of malignant histiocytosis (MH) with tissue microarray technique.</p><p><b>METHODS</b>Using tissue-chips, immunohistochemical staining, in situ hybridization and PCR to analyze 5 autopsy cases of MH.</p><p><b>RESULTS</b>(1) In all 5 cases, positive reactions of CD45RO, CD3 epsilon, TIA-1, Granzyme B were detected in the neoplastic cells, whereas negative reactions were found with CD30, CD20, CD56. (2) All cases revealed EBER1/2 positivity in neoplastic cells.</p><p><b>CONCLUSION</b>Previously diagnosed malignant histiocytosis is an EBV-associated aggressive NK/T cell lymphoma.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Virologia
/
Imuno-Histoquímica
/
Reação em Cadeia da Polimerase
/
Linfoma de Células T
/
Hibridização In Situ
/
Infecções por Vírus Epstein-Barr
/
Alergia e Imunologia
/
Sarcoma Histiocítico
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Pathology
Ano de publicação:
2002
Tipo de documento:
Artigo
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