Prognostic role of apoptosis-related gene Fas-1377 and -670 polymorphisms in breast cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 104-107, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-255552
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlations between Fas-1377 and -670 polymorphisms and survival in Chinese women with breast cancer.</p><p><b>METHODS</b>Polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP) was used to detect the polymorphism of Fas gene in 310 breast cancer patients with a long-term follow-up (median 10.5 years, range 0.2 - 16.1 years). Survival curves were analyzed by Kaplan-Meier method.</p><p><b>RESULTS</b>The polymorphism of neither Fas-1377 nor Fas-670 was significantly correlated with the overall survival in this series of 310 cases (P > 0.05). However, among 146 patients without lymph node metastasis, the 5-year overall survival (OS) rate was significantly lower in the patients with Fas-1377 AA genotype than that in the patients with Fas-1377 GA or GG genotype (OS 66.7% vs. 95.4%, P = 0.03). Among 117 patients with lymph node metastasis, both the Fas-1377 and Fas-670 polymorphisms were not significantly correlated with OS (P = 0.42).</p><p><b>CONCLUSION</b>Among breast cancer patients without lymph node metastasis, patients with Fas-1377 AA genotype may have a worse survival, while patients with Fas-1377 GA or GG genotype may not be so.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Polimorfismo Genético
/
Prognóstico
/
Neoplasias da Mama
/
Taxa de Sobrevida
/
Seguimentos
/
Apoptose
/
Receptor fas
/
Genética
/
Metástase Linfática
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2009
Tipo de documento:
Artigo
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