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Variations in the calpain-10 gene are associated with the risk of type 2 diabetes and hypertension in northern Han Chinese population / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 2218-2223, 2007.
Artigo em Inglês | WPRIM | ID: wpr-255809
ABSTRACT
<p><b>BACKGROUND</b>Calpain-10 (CAPN10) has been identified as a susceptibility gene in type 2 diabetes mellitus (T2DM) and insulin resistance. The present study aimed to identify the effects of genetic variations in the CAPN10 gene on the development of type 2 diabetes and hypertension in northern Han Chinese population.</p><p><b>METHODS</b>We performed a case-control study and genotyped single nucleotide polymorphism (SNP)-44, -43, -19 and -63 of CAPN10 gene in 1046 subjects from the northern China, including 493 patients with T2DM and hypertension and 553 age- and gender-matched normal healthy controls.</p><p><b>RESULTS</b>Univariate analysis showed that the four polymorphisms were not independently associated with T2DM and hypertension. However, the frequency distributions of SNP-44 allele C (allele 2) (17.89% vs 9.80%, P = 0.0016) and genotype CC (22) (4.21% vs 1.01%, P = 0.0059) in obese patients (body mass index > or = 30 kg/m2) were different from those in non-obese patients. Logistic regression analyses revealed that carriers of the 1112/1221 diplotype had a significantly lower odds ratio for diabetes and hypertension (OR = 0.399, 95% CI, 0.196 - 0.814, P = 0.0115). The 1112/1121 diplotype associated with significantly increased risk of type 2 diabetes in Mexican-American was not associated with the increased risk in Chinese.</p><p><b>CONCLUSION</b>These results suggested that CAPN10 gene variations might play roles in the risk of diabetes and hypertension in northern Han Chinese population.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Haplótipos / Calpaína / Desequilíbrio de Ligação / China / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Locos de Características Quantitativas / Diabetes Mellitus Tipo 2 / Etnologia / Genética Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo prognóstico Limite: Adulto / Idoso / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Inglês Revista: Chinese Medical Journal Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Haplótipos / Calpaína / Desequilíbrio de Ligação / China / Predisposição Genética para Doença / Polimorfismo de Nucleotídeo Único / Locos de Características Quantitativas / Diabetes Mellitus Tipo 2 / Etnologia / Genética Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo prognóstico Limite: Adulto / Idoso / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Inglês Revista: Chinese Medical Journal Ano de publicação: 2007 Tipo de documento: Artigo