Clinical and experimental study of 7 cases of acute lymphoblastic leukemia with dic(7;9) (pll;pll) / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 485-488, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-255854
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the laboratory and clinical features of 7 cases of acute lymphoblastic leukemia (ALL) with dic(7;9) (pll;pll).</p><p><b>METHODS</b>Cytogenetic examination of bone marrow cells was performed by direct method or short-term culture method. R banding technique was used for karyotype analysis. bcr/abl fusion gene was detected by interphase FISH using dual-color bcr/abl probe in 6 cases. FISH using chromosome 7-specific alpha-satellite DNA probe and chromosome 9-specific alpha-satellite DNA probe and chromosome painting using whole chromosome 7 and 9 paints probes were performed respectively.</p><p><b>RESULTS</b>Seven (0.88%) of 800 ALL patients were found to have dic(7;9) abnormality. Among them, dic(7;9) was the sole abnormality in 2 cases, t(9;22), other additional aberrations besides dic(7;9) in 4 cases and dic (7;9) with other abnormalities but no t(9;22) in one case. Hyperleukocytosis (> 100 x 10(9)/L) was found in 4 cases with dic(7;9) and t(9;22), and patients without t(9;22) had WBC < 100 x 10(9)/L. Enlargement of liver, spleen and/or lymph nodes were found in 6 cases. Immunophenotyping showed that 5/6 cases of dic (7;9) ALL were of B lineage. Dual-color FISH detected bcr/abl rearrangement in 3/6 cases and confirmed that the centromere of the derivative chromosome was originated from both chromosomes 7 and 9. A reciprocal translocation between chromosomes 7 and 9 was proved by chromosome painting.</p><p><b>CONCLUSION</b>dic(7;9) was a rare, but recurrent chromosome abnormality in ALL and had some clinical and laboratory features.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Translocação Genética
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Cromossomos Humanos Par 7
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Cromossomos Humanos Par 9
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Hibridização in Situ Fluorescente
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Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Genética
/
Cariotipagem
Limite:
Adolescente
/
Adulto
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Criança
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Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2005
Tipo de documento:
Artigo
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