Prognostic analysis of 51 cases of primary nodal diffuse large B-cell lymphomas / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 223-226, 2005.
Artigo
em Chinês
| WPRIM
| ID: wpr-255902
ABSTRACT
<p><b>OBJECTIVE</b>To explore the prognostic factors of primary nodal diffuse large B-cell lymphomas (N-DLBCL).</p><p><b>METHODS</b>According to the 2001 WHO classification of tumors of hematopoietic and lymphoid tissue, 51 cases of primary N-DLBCL were collected for clinical data analysis and immunohistochemical assay. Antibodies used for study were anti-CD20, CD79alpha, CD45RO, CD3, Bcl-2, Ki-67, CD30, CD15, kappa, lambda, Cyclin D1, TdT, GFAP, CK, MPO. The survival data was analyzed.</p><p><b>RESULTS</b>Of the 51 cases of N-DLBCLs, 40 were reclassified as centroblastic, 3 B-immunoblastic, 1 T-cell/histiocytes rich, 2 B-cell anaplastic large cell, 1 plasmablastic, and 4 unclassified. Expression of Bcl-2 oncoprotein was observed in 24 cases (47.1%). The median Ki-67 index was 50.0% and the index more than 40% was found in 35 cases (68.6%). Survival analysis of 35 cases had follow up data showed that the 2 year and 5-year overall survival (OS) rates were 48.54% and 35.30%, respectively. The 5-year OS rates patients with International Prognosis Index (IPI) >/= 3 was lower than that with IPI < 3 (P < 0.01). The 5-year OS rates for patients with B symptoms was lower than that without B symptoms (P < 0.05). The 5-year OS rates for patients with Ki-67 index more than 40% was lower than that with less than 40% (P < 0.05). The expression of Bcl-2 oncoprotein was uncorrelated to prognosis (P > 0.05).</p><p><b>CONCLUSION</b>IPI, B symptoms and Ki-67 index are the prognostic factors for patients with N-DLBCL.</p>
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DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Prognóstico
/
Imuno-Histoquímica
/
Análise de Sobrevida
/
Seguimentos
/
Antígenos CD15
/
Linfoma Difuso de Grandes Células B
/
Antígenos Comuns de Leucócito
/
Antígeno Ki-1
/
Antígenos CD20
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Idoso
/
Aged80
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2005
Tipo de documento:
Artigo
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