Urticarial Dermatitis: Clinical Characteristics of Itch and Therapeutic Response to Cyclosporine
Annals of Dermatology
;
: 143-148, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-25593
ABSTRACT
BACKGROUND:
Urticarial dermatitis, which is characterised by persistent wheals with eczematous papules and plaques, is frequently misdiagnosed and difficult to treat. Patients commonly experience intolerable pruritus which may greatly affect their quality of life.OBJECTIVE:
The objective of this study is to characterize the clinical patterns of pruritus in patients with urticarial dermatitis and to determine the effectiveness of cyclosporine treatment.METHODS:
This prospective study included 50 histopathologically confirmed patients with urticarial dermatitis. A face-to-face structured questionnaire was given to all patients, and they were treated with low-dose cyclosporine (1~3 mg/kg/d) for at least 2 weeks.RESULTS:
The majority of patients (80.0%) had moderate to severe pruritus. Most patients experienced exacerbation of the itch in the evening (74.0%), with the extremities (upper, 86.0%; lower, 94.0%) being the most commonly involved sites. Due to severe pruritus, patients complained about reduced social contact, quality of life and difficulties in falling asleep et al. Cyclosporine significantly reduced the mean itch score and extent of erythema, and improved interference with daily activities and sleep.CONCLUSION:
Our study highlights the detailed description and characteristics of pruritus in patients with urticarial dermatitis. And we recommend alternative and effective therapeutic option of low-dose cyclosporine.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prurido
/
Qualidade de Vida
/
Acidentes por Quedas
/
Estudos Prospectivos
/
Ciclosporina
/
Dermatite
/
Eritema
/
Extremidades
Tipo de estudo:
Estudo observacional
/
Pesquisa qualitativa
Limite:
Humanos
Idioma:
Inglês
Revista:
Annals of Dermatology
Ano de publicação:
2017
Tipo de documento:
Artigo
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