CREB-regulated transcription coactivator 1: important roles in neurodegenerative disorders / 生理学报
Acta Physiologica Sinica
;
(6): 155-162, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-255962
ABSTRACT
The cAMP-responsive element binding protein (CREB)-regulated transcription coactivator, CRTC (also known as transducer of regulated CREB, TORC), is identified as a potent modulator of cAMP response element (CRE)-driven gene transcription. The CRTC family consists of three members (CRTC1-3), among which the CRTC1 shows the highest expression in the brain. Several studies have demonstrated that the CRTC1 plays critical roles in neuronal dendritic growth, long-term synaptic plasticity, memory consolidation and reconsolidation etc., whereas dysfunction of CRTC1 is mainly involved in neurodegenerative disorders. In light of these findings, we aim to review recent research reports that indicate the CRTC1 dysfunction and its underlying mechanisms in the neurodegenerative disorders.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Fatores de Transcrição
/
Encéfalo
/
Doenças Neurodegenerativas
/
Dendritos
/
Plasticidade Neuronal
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2015
Tipo de documento:
Artigo
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