Progress of study on p62 and protein degradation pathways / 生理学报
Acta Physiologica Sinica
;
(6): 48-58, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-255973
ABSTRACT
The p26, a multifunctional ubiquitin-binding protein, has been proposed to be involved in protein degradation as a component within the ubiquitin-proteasome and autophagy-lysosome systems. As a scaffolding protein with several different kinds of protein-protein interaction domains, p62 mediates various cellular functions. Importantly, p62 plays a critical role in cell's selective autophagy and oxidative stress response, which are associated with the pathogenesis of several human diseases. In this review, we describe the structure of p62 and the mechanism of connection between p62 and ubiquitin-proteasome system/autophagy, so as to provide some perspectives on p62 research.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Autofagia
/
Estresse Oxidativo
/
Ubiquitina
/
Complexo de Endopeptidases do Proteassoma
/
Proteínas Adaptadoras de Transdução de Sinal
/
Domínios e Motivos de Interação entre Proteínas
/
Proteólise
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2015
Tipo de documento:
Artigo
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