Effect of puerarin and daidzein on proliferating vascular smooth muscle cells / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 437-440, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-256333
ABSTRACT
<p><b>OBJECTIVE</b>To observe the different effects of Puerarin and Daidzein on the expression of proliferating vascular smooth muscle cells, and to discuss the mechanism.</p><p><b>METHOD</b>MT was used to detect the state of VSMC (vascular smooth muscle cell) activity. The expression levels of Survivin, Bcl-xl, Bax and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) messenger RNA (mRNA) were analyzed quantitatively by reverse transcriptase polymerase chain reaction (Rt-PCR).</p><p><b>RESULT</b>Compared with Puerarin groups, VSMC activity in daidzein groups was lower, and the ratio of Bax/Gapdh/Bcl-xl/Gapdh was higher.</p><p><b>CONCLUSION</b>The inhibition effect of daidzein on VSMC proliferation is stronger than that of puerarin.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Plantas Medicinais
/
Vasodilatadores
/
RNA Mensageiro
/
Células Cultivadas
/
Química
/
Regulação da Expressão Gênica
/
Proteínas Proto-Oncogênicas c-bcl-2
/
Pueraria
/
Biologia Celular
Limite:
Humanos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2004
Tipo de documento:
Artigo
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