Effect of Spatholobus suberectus on the bone marrow cells and related cytokines of mice / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 352-355, 2004.
Article
em Zh
| WPRIM
| ID: wpr-256355
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Spatholobus suberectus on proliferation and the hematonic mechanism.</p><p><b>METHOD</b>The techniques of culture of hematopoietic cell and hematopoietic growth factor (HGF) assay were used.</p><p><b>RESULT</b>Spatholobus suberectus could obviously promote the proliferation of bone marrow cells in healthy and anaemic mice. The culture media of spleen cell, macrophage, lung and skeletal muscle treated with S. suberectus had much stronger stimulating effects on hematopoietic cells.</p><p><b>CONCLUSION</b>S. suberectus may enhance hematopoiesis by directly or indirectly stimulating stroma cell in hematopoietic inductive microenvironment and muscle tissue to secrete some HGF (Epo, GM-CSF, IL, and MK-CSF). This is one of the biological mechanisms for hematonic effect of S. suberectus.</p>
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Índice:
WPRIM
Assunto principal:
Patologia
/
Farmacologia
/
Plantas Medicinais
/
Células da Medula Óssea
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Medicamentos de Ervas Chinesas
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Química
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Fatores Estimuladores de Colônias
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Caules de Planta
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Biologia Celular
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Proliferação de Células
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2004
Tipo de documento:
Article