Role of tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) axis in rheumatic diseases / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 3898-3904, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-256621
ABSTRACT
Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a member of the TNF superfamily of structurally related cytokines and is known to induce proliferation, migration, differentiation, apoptotic cell death, inflammation, and angiogenesis. These physiological processes are induced by the binding of TWEAK to fibroblast growth factor-inducible 14 (Fn14), a highly inducible cell-surface receptor that is linked to several intracellular signaling pathways, including the nuclear factor-κB (NF-κB) pathway. This review discusses the role of the TWEAK-Fn14 axis in several rheumatic diseases and the potential therapeutic benefits of modulation of the TWEAK-Fn14 pathway.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Artrite Reumatoide
/
Escleroderma Sistêmico
/
Doenças Reumáticas
/
Receptores do Fator de Necrose Tumoral
/
Fatores de Necrose Tumoral
/
Citocina TWEAK
/
Receptor de TWEAK
/
Lúpus Eritematoso Sistêmico
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2012
Tipo de documento:
Artigo
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