The effect of pulsed electromagnetic fields on beta-TCP graft in rabbit cranial bone defect
Journal of the Korean Association of Oral and Maxillofacial Surgeons
; : 360-373, 2006.
Article
em Ko
| WPRIM
| ID: wpr-25666
Biblioteca responsável:
WPRO
ABSTRACT
The purpose of this research was to investigate whether pulsed electromagnetic field (PEMF) stimulation applied to the rabbit cranial defects grafted with beta-tricalcium phosphate (beta-TCP) could affect the new bone formation. With 16 New Zealand white rabbits under the same condition, bilateral calvarial bone defects were formed around the sagittal suture line. The defect on the left side was grafted with beta-TCP, while on the right side was grafted by harvested autogenous bone. PEMF was applied to 8 rabbits for 8 hours per day. The bony specimen were divided into 3 groups, the group 1 was autogenous bone grafted specimen, the group 2 was beta-TCP grafted with PEMF, and the group 3 was beta-TCP grafted without PEMF. We investigated the bone regeneration and growth factor expression at 2, 4, 6, and 8 weeks. As a result, BMP 2 was expressed in the group 1 from 2 weeks, the group 2 from 4 weeks, and the group 3 from 6 weeks. BMP 4 was expressed in the group 1 from 2 weeks, in the group 2 and the group 3 from 4 weeks. 4. There was no significant difference in expression pattern of BMP 7, PDGF, VEGF, and TGF-beta1 during grafted bone regeneration in group 1, 2, and 3. According to our results, PEMF stimulation could be effective on the new bome formation in animal study, and have a feasibility of clinical use.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Osteogênese
/
Suturas
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Regeneração Óssea
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Transplantes
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Fator A de Crescimento do Endotélio Vascular
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Campos Eletromagnéticos
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Fator de Crescimento Transformador beta1
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Imãs
Limite:
Animals
Idioma:
Ko
Revista:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Ano de publicação:
2006
Tipo de documento:
Article