Detection of serum endothelial cell specific molecule 1 in gastric cancer patients and its clinical significance / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 51-55, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-256819
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of serum endothelial cell specific molecule 1 (ESM-1) in gastric cancer and to evaluate the effect of serum ESM-1 as a potential serum biomarker.</p><p><b>METHODS</b>Serum ESM-1 was detected by enzyme-linked immunosorbent assay (ELISA) and CEA, CA19.9, CA72.4 were detected by electrochemiluminescence immunoassay (ECLIA) in 102 patients with gastric cancer preoperatively. At the same time, serum ESM-1, CEA, CA19-9, CA72-4 in 41 healthy adults volunteers were detected with the same method. In addition, the follow-up data of all the patients were collected.</p><p><b>RESULTS</b>Compared to healthy volunteers, the serum ESM-1 level in gastric cancer patients increased (P<0.01). The sensitivity and specificity of serum ESM-1 were 73.9% and 51.2% respectively. In contrast, the sensitivities of CEA, CA19-9 and CA72-4 were only 16.1%, 18.3% and 23.2% respectively. High level of serum ESM-1 indicated poor outcomes (P<0.05).</p><p><b>CONCLUSIONS</b>Serum ESM-1 increases in the peripheral blood of the gastric cancer patients. It may be a potential serum marker to help diagnosis and prediction of prognosis of gastric cancer patients.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteoglicanas
/
Neoplasias Gástricas
/
Sangue
/
Biomarcadores Tumorais
/
Estudos de Casos e Controles
/
Sensibilidade e Especificidade
/
Diagnóstico
/
Proteínas de Neoplasias
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Aged80
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Gastrointestinal Surgery
Ano de publicação:
2014
Tipo de documento:
Artigo
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