Lipopolysaccharide affects male reproductive function through Toll-like receptors / 中华男科学杂志
National Journal of Andrology
;
(12): 163-168, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-256942
ABSTRACT
Reproductive tract infection is one of the factors of male infertility, but the mechanisms responsible are hitherto poorly defined. Recent studies show that one of the microbial pattern-recognition receptors, Toll-like receptor (TLR) signaling pathway, plays a critical role in inflammation-induced male infertility. Lipopolysaccharide (LPS), a major component in the cell wall of gram-negative bacteria, could induce inflammatory response through TLRs. A large number of researches suggest that TLRs express widely in the male reproductive tract and LPS-induced inflammatory reaction through TLRs may affect male fertility. This article presents an overview on how LPS-induced inflammation through TLRs affects male fertility in terms of its influence on the testis, epididymis and sperm quality.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Lipopolissacarídeos
/
Receptores Toll-Like
/
Doenças dos Genitais Masculinos
/
Bactérias Gram-Negativas
/
Infertilidade Masculina
/
Inflamação
/
Metabolismo
Limite:
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2013
Tipo de documento:
Artigo
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