Vaccines against periodontitis: a forward-looking review
Journal of Periodontal & Implant Science
;
: 153-163, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-25697
ABSTRACT
Periodontal disease, as a polymicrobial disease, is globally endemic as well as being a global epidemic. It is the leading cause for tooth loss in the adult population and has been positively related to life-threatening systemic diseases such as atherosclerosis and diabetes. As a result, it is clear that more sophisticated therapeutic modalities need to be developed, which may include vaccines. Up to now, however, no periodontal vaccine trial has been successful in satisfying all the requirements; to prevent the colonization of a multiple pathogenic biofilm in the subgingival area, to elicit a high level of effector molecules such as immunoglobulin sufficient to opsonize and phagocytose the invading organisms, to suppress the induced alveolar bone loss, or to stimulate helper T-cell polarization that exerts cytokine functions optimal for protection against bacteria and tissue destruction. This article reviews all the vaccine trials so as to construct a more sophisticated strategy which may be relevant in the future. As an innovative strategy to circumvent these barriers, vaccine trials to stimulate antigen-specific T-cells polarized toward helper T-cells with a regulatory phenotype (Tregs, CD4+, CD25+, FoxP3+) have also been introduced. Targeting not only a single pathogen, but polymicrobial organisms, and targeting not only periodontal disease, but also periodontal disease-triggered systemic disease could be a feasible goal.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças Periodontais
/
Periodontite
/
Fenótipo
/
Bactérias
/
Imunoglobulinas
/
Vacinas
/
Linfócitos T
/
Perda do Osso Alveolar
/
Perda de Dente
/
Imunização
Limite:
Adulto
/
Humanos
Idioma:
Inglês
Revista:
Journal of Periodontal & Implant Science
Ano de publicação:
2010
Tipo de documento:
Artigo
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