The mechanism of action of valsartan studied by HPLC-TOF/MS / 药学学报
Acta Pharmaceutica Sinica
; (12): 875-881, 2015.
Article
em Zh
| WPRIM
| ID: wpr-257053
Biblioteca responsável:
WPRO
ABSTRACT
High performance liquid chromatography-time-off-flight mass spectrometer (HPLC-TOFMS) technology coupled with partial least squares discriminant analysis (PLS-DA) processed by SIMCA-P software was applied to investigate serum endogenous metabolites alternations of valsartan in spontaneous hypertension rats (SHR). And MetPA platform was used to connect identified potential biomarkers in corresponding metabolic pathways to find possible therapeutic mechanism of valsartan. Valsartan significantly declined the blood pressure of SHRs (P < 0.05) at fourth week. The metabolic profiling significantly changed and four metabolites involved in G protein-coupled pathway were identified. Metabolomics is able to detect holistic and microcosmic alternations in organism, so as to elucidate therapeutic mechanism of drugs.
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Índice:
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Assunto principal:
Farmacologia
/
Ratos Endogâmicos SHR
/
Espectrometria de Massas
/
Sangue
/
Pressão Sanguínea
/
Biomarcadores
/
Análise Discriminante
/
Análise dos Mínimos Quadrados
/
Cromatografia Líquida de Alta Pressão
/
Metaboloma
Limite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2015
Tipo de documento:
Article