Eukaryotic elongation factor 2 kinase and cancer / 药学学报
Acta Pharmaceutica Sinica
;
(12): 808-813, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-257063
ABSTRACT
Eukaryotic elongation factor 2 kinase (eEF2K) is well known as a Ca2+/calmodulin (CaM)-dependent kinase. eEF2K catalyzes the phosphorylation of eEF2 and subsequently inactivates eEF2 by impairing its ability to bind to the ribosome, thereby negatively modulates protein synthesis. The high expression of eEF2K has been found recently in several types of malignancies. As participating in the progress of tumor, eEF2K emerges a potential target for future cancer therapy. The relationship between eEF2K and tumor, and the latest progress of eEF2K inhibitors were summarized in this article.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosforilação
/
Fator 2 de Elongação de Peptídeos
/
Quinase do Fator 2 de Elongação
/
Metabolismo
/
Neoplasias
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2015
Tipo de documento:
Artigo
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