Chemical constituents from Morus notabilis and their cytotoxic effect / 药学学报
Acta Pharmaceutica Sinica
;
(12): 579-582, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-257098
ABSTRACT
Une new flavonoids named as notabilisin K (1), together with four known compounds, morusin (2), mulberrofuran A (3), neocyclomorusin (4) and mornigrol F (5) are separated from 95% ethanol extracts of the twigs of Morus notabilis. Compounds 2-5 are separated from this plant for the first time. Notabilisin I, notabilisin J exhibits certain effect against cells of HCT-116, HepG2 and A2780 with IC50 values ranging from 1.47 μmol x L(-1) to 5.46 μmol x L(-1). Morusin exhibits strong effect against five kinds of human cancer cells (BGC823, A2780, HCT-116, HepG2 and NCI-H1650) with IC50 values ranging from 0.74 μmol x L(-1) to 1.58 μmol x L(-1).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terpenos
/
Benzofuranos
/
Flavonoides
/
Extratos Vegetais
/
Química
/
Concentração Inibidora 50
/
Morus
/
Células Hep G2
/
Antineoplásicos Fitogênicos
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2015
Tipo de documento:
Artigo
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