Induction effects of sulfur dioxide inhalation on chromosomal aberrations in mouse bone marrow cells / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 229-231, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-257260
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the induction effects of sulfur dioxide (SO(2)) inhalation on chromosomal aberrations (CA) in mouse bone marrow cells.</p><p><b>METHODS</b>The mice were treated with SO(2) for 4 h/day x 7 days at various concentrations of SO(2), then mitotic indices and CA in the bone marrow cells were analyzed.</p><p><b>RESULTS</b>SO(2) increase the frequencies of CA and aberrant cells in mouse bone marrow cells in dose-dependent manner. The frequencies (%) of the aberrant cells in mouse bone marrow cells induced by SO(2) at concentrations of 0, 14, 28, 56 and 84 mg/m(3) were 1.81, 3.00, 3.58, 4.26 and 4.86, respectively. SO(2) at low concentrations induced only chromatid-type CA, but at high concentrations it induced both chromatid-type and chromosome-type CA. SO(2) inhalation decreased the mitotic indices of the bone marrow cells.</p><p><b>CONCLUSIONS</b>SO(2) inhalation may inhibit mitoses and increase CA frequencies of the bone marrow cells; therefore, it is a clastogenetic and genotoxic agent. It implies that long time exposure of SO(2) pollutant at low concentration in air may be a potential risk to induce damage of cytogenetic material in humans.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Dióxido de Enxofre
/
Administração por Inalação
/
Células da Medula Óssea
/
Aberrações Cromossômicas
/
Relação Dose-Resposta a Droga
/
Metabolismo
/
Índice Mitótico
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Preventive Medicine
Ano de publicação:
2002
Tipo de documento:
Artigo
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