Caspase-3 and survivin expression in pediatric neuroblastoma and their roles in apoptosis / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 1821-1824, 2004.
Article
em En
| WPRIM
| ID: wpr-257353
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Neuroblastoma, one of the common tumors in children, possesses the feature of natural regression that might be related to apoptosis caspase-3 and survivin are believed to respectively induce and inhibit apoptosis. We investigated the expression of caspase-3 and survivin in pediatric neuroblastoma and the role that these genes played in apoptosis.</p><p><b>METHODS</b>The expression of caspase-3 and survivin in pediatric neuroblastoma tissue samples was detected using in situ hybridization, ter mintuesal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL), and immunohistochemical staining. The role that these genes played in apoptosis was then evaluated.</p><p><b>RESULTS</b>A converse correlation was observed between the expression of survivin and caspase-3. When survivin was expressed at high levels in neuroblastoma samples, caspase-3 expression was downregulated, and the apoptotic index decreased simultaneously.</p><p><b>CONCLUSION</b>There is a converse correlation between the expression of caspase-3 and the expression of survivin in neuroblastoma cells, indicating that caspase-3 might induce apoptosis, and survivin may inhibit this process.</p>
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Índice:
WPRIM
Assunto principal:
Patologia
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Fisiologia
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Imuno-Histoquímica
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Química
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Apoptose
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Caspases
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Proteínas Inibidoras de Apoptose
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Caspase 3
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Proteínas Associadas aos Microtúbulos
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Proteínas de Neoplasias
Limite:
Female
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Humans
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Infant
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Male
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Newborn
Idioma:
En
Revista:
Chinese Medical Journal
Ano de publicação:
2004
Tipo de documento:
Article