Expression of HAT1 and HDAC1, 2, 3 in Diffuse Large B-Cell Lymphomas, Peripheral T-Cell Lymphomas, and NK/T-Cell Lymphomas
Korean Journal of Pathology
;
: 142-150, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-25785
ABSTRACT
BACKGROUND:
It has generally been proven that histone acetylation and deacetylation are involved in the malignant transformation. To date, however, this has rarely been studied in cases of malignant lymphoma.METHODS:
We studied nine cases of reactive lymphoid hyperplasia, 78 cases of diffuse large B-cell lymphoma (DLBCL), 13 cases of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and 13 cases of extranodal NK/T-cell lymphoma, nasal type (NKTCL). Thus, we attempted to elucidate the associations of the degree of the expression of histone acetyltransferase 1 (HAT1), histone deacetylase (HDAC) 1, HDAC2, and HDAC3 with the clinical behaviors of above malignant lymphomas using the immunohistochemistry and a western blot analysis.RESULTS:
The degree of the expression of HAT1 was higher in cases of DLBCL, PTCL-NOS or NKTCL as compared with reactive lymphoid hyperplasia (p0.05).CONCLUSIONS:
HAT1, HDAC1, and HDAC2 play a critical role in the development of malignant lymphomas. Both HAT1 and HDAC1 might be indicators for a poor prognosis in cases of DLBCL as cooperating factors.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Acetilação
/
Prognóstico
/
Imuno-Histoquímica
/
Linfócitos B
/
Histonas
/
Western Blotting
/
Linfoma de Células B
/
Linfoma de Células T Periférico
/
Pseudolinfoma
/
Histona Acetiltransferases
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Korean Journal of Pathology
Ano de publicação:
2012
Tipo de documento:
Artigo
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