Effect of glycogen on calcium of donor liver during ischemia-reperfusion period / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 21-24, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-257898
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of glycogen on calcium concentration of rabbit donor liver during ischemia-reperfusion period.</p><p><b>METHODS</b>Donor group (n=21) was divided into 3 subgroups randomly Group A (n=7) fasting for 24 hours before harvesting; Group B (n=7) normal laboratory chew; Group C (n=7) normal laboratory chew plus glucose supplement intravenously. Based on the self-created animal model for ischemia-reperfusion, the levels of glycogen content, ATP level, viability of Ca(2+)ATPase and plasmic free Ca(2+) concentration ([Ca(2+)]i) of liver tissue were measured.</p><p><b>RESULTS</b>Before cold preservation, there was a significant difference of glycogen content among the three groups at all time points except at the end of rewarming period. ATP level and Ca(2+)ATPase viability were significantly higher in group C than in other two groups. But the plasmic free Ca(2+) concentration was lower in groups with higher glycogen content.</p><p><b>CONCLUSIONS</b>Donor liver with high glycogen content can provide relatively sufficient ATP, maintain better Ca(2+)ATPase viability and prevent plasmic free Ca(2+) concentration overloading. This maybe an important mechanism for glycogen to ameliorate ischemia-reperfusion injury to the donor livers.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Traumatismo por Reperfusão
/
Trifosfato de Adenosina
/
Química
/
Cálcio
/
Transplante de Fígado
/
ATPases Transportadoras de Cálcio
/
Modelos Animais
/
Citosol
/
Glicogênio
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2002
Tipo de documento:
Artigo
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