The role of human herpesvirus-8 infection in the pathogenesis of multiple myeloma / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 81-84, 2002.
Artigo
em Chinês
| WPRIM
| ID: wpr-258063
ABSTRACT
Multiple myeloma is a B-cell neoplasm characterized by abnormal proliferation and accumulation of monoclonal plasma cells in the bone marrow. Recently some laboratories have detected human herpesvirus-8 (HHV-8) DNA sequences in bone marrow dendritic cells from myeloma patients. It has been suggested that the cytokines expressed by HHV-8 gene, such as vIRF, vIL-8R and vIL-6, may play a role in the pathogenesis of multiple myeloma. However, the majority of European investigators failed to find evidence to confirm this observation. It remains unclear whether HHV-8 is consequentially associated with myeloma or only a regional opportunistic infection. Controversy still focuses on the role of specific HHV-8 strains involved in pathogenesis of multiple myeloma and causality between the
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Virologia
/
Células Dendríticas
/
Estudos Soroepidemiológicos
/
Epidemiologia
/
Citocinas
/
Infecções por Herpesviridae
/
Herpesvirus Humano 8
/
Alergia e Imunologia
/
Metabolismo
Tipo de estudo:
Estudo de etiologia
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2002
Tipo de documento:
Artigo
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