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Expressions of wildtype-RET and RET/PTC rearrangements in sporadic adult papillary thyroid carcinoma and their clinicopathologic correlation / 中华病理学杂志
Chinese Journal of Pathology ; (12): 87-91, 2006.
Artigo em Chinês | WPRIM | ID: wpr-258216
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the expressions of wildtype-RET (WT-RET) and RET/PTC in sporadic adult papillary thyroid carcinoma and to investigate their clinicopathologic correlation.</p><p><b>METHODS</b>Sixty-six papillary thyroid carcinomas (PTC) and thirty-six control cases with frozen and paraffin-embedded tissues were analyzed for the expressions of WT-RET and oncogene RET/PTC1 or RET/PTC3 by nested RT-PCR.</p><p><b>RESULTS</b>(1) 62 percent (41/66) of PTC patients were above 40 years of age. Thirty-eight percent (25/66) of the tumors showed lymphocytic thyroiditis. Lymph node and distant metastasis were seen in 59% (39/66) and 7.6% (5/66) respectively. (2) Forty-five cases (68.1%) of PTCs expressed RET tyrosine kinase domain (RET-TK). Simultaneous expressions of RET-BP and TK were seen in nineteen PTCs (28.8 %). One of eight adenomas (12.5 %) expressed wild-type RET (WT-RET). (3) Fourteen PTCs (21.2%) expressed RET/PTC, including five cases expressing RET/PTC1 and nine cases expressing RET/PTC3. Six cases (9%) expressed both RET/PTC and WT-RET. (4) Statistic analysis did not show any correlation between the expression of WT-RET or RET/PTC and clinicopathologic parameters.</p><p><b>CONCLUSIONS</b>The expression of RET/PTC was specific to PTC. However, its prevalence was low and, therefore, of limited diagnostic utility. The expression patterns of WT-RET in PTC and adenoma suggest that there are different molecular mechanisms in activating RET proto-oncogene in thyroid tumors.</p>
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Proteínas Tirosina Quinases / RNA Mensageiro / Neoplasias da Glândula Tireoide / Carcinoma Papilar / Rearranjo Gênico / Adenoma / Proteínas de Fusão Oncogênica / Doença de Hashimoto / Proteínas Proto-Oncogênicas c-ret Limite: Adolescente / Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Pathology Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Patologia / Proteínas Tirosina Quinases / RNA Mensageiro / Neoplasias da Glândula Tireoide / Carcinoma Papilar / Rearranjo Gênico / Adenoma / Proteínas de Fusão Oncogênica / Doença de Hashimoto / Proteínas Proto-Oncogênicas c-ret Limite: Adolescente / Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Chinês Revista: Chinese Journal of Pathology Ano de publicação: 2006 Tipo de documento: Artigo