Prognostic factors for 72 patients with osteosarcoma of the extremity treated with neoadjuvant chemotherapy / 中华外科杂志
Chinese Journal of Surgery
;
(12): 1166-1170, 2008.
Artigo
em Chinês
| WPRIM
| ID: wpr-258309
ABSTRACT
<p><b>OBJECTIVE</b>To determine the prognostic factors that influence survival of patients with non-metastatic, high-grade osteosarcoma of the extremities.</p><p><b>METHODS</b>The data of 72 patients treated between June 2003 and June 2007, was retrospectively evaluated in relation to many factors including gender, age, etc.</p><p><b>RESULTS</b>Tumor necrosis was significantly related to gender, tumor volume change, tumor margin and T2 signal intensity of the extraosseous component of bone sarcomas. Multivariate analysis, tumor necrosis was only related to tumor volume change. Upon multivariate analysis, good histologic response was related to the outcome of patients.</p><p><b>CONCLUSIONS</b>Event free survival is related to the tumor necrosis, the level of alkaline phosphatase and the change of T2 signal of the extraosseous component. Tumor necrosis is related to the volume change after preoperative chemotherapy. These factors must be considered when deciding risk-adapted treatments for patients with osteosarcoma.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Prognóstico
/
Cirurgia Geral
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Osteossarcoma
/
Análise de Sobrevida
/
Estudos Retrospectivos
/
Resultado do Tratamento
/
Quimioterapia Adjuvante
/
Usos Terapêuticos
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Surgery
Ano de publicação:
2008
Tipo de documento:
Artigo
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