The α(2A)-adrenoceptor agonist guanfacine improves spatial learning but not fear conditioning in rats / 生理学报
Acta Physiologica Sinica
;
(6): 739-744, 2007.
Artigo
em Inglês
| WPRIM
| ID: wpr-258601
ABSTRACT
It is known that stimulation of the α(2A)-adrenoceptors (α(2A)-ARs) by the selective α(2A)-AR agonist guanfacine produces an important and beneficial influence on prefrontal cortical (PFC) cognitive functions such as spatial working memory and selective attention. However, it is unclear whether stimulation of the α(2A)-ARs has a similar effect on fear conditioning that involves the amygdala and hippocampus. Here, we show that systemically administered guanfacine significantly enhances spatial learning of rats in the Lashley maze compared with controls, the rats treated with guanfacine required significantly fewer trials and made significantly fewer errors to reach learning criterion. However, guanfacine produced no effect on acquisition of contextual and auditory fear memories. The present study suggests that beneficial effect of α(2A)-AR stimulation is task-dependent guanfacine improves spatial learning but not fear conditioning.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Comportamento Espacial
/
Comportamento Animal
/
Guanfacina
/
Aprendizagem em Labirinto
/
Condicionamento Psicológico
/
Medo
/
Agonistas de Receptores Adrenérgicos alfa 2
/
Memória
Limite:
Animais
Idioma:
Inglês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2007
Tipo de documento:
Artigo
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