Progress in endogenous cardioprotection induced by ischemic postconditioning / 生理学报
Acta Physiologica Sinica
;
(6): 628-634, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-258613
ABSTRACT
Restoration of blood flow is the definitive therapy to salvage myocardium following ischemic injury. Sudden restoration of blood flow to the ischemic myocardium may, however, also cause reperfusion injury. Therefore, to prevent such ischemia/reperfusion (I/R) injury, one strategy could be to evoke endogenous myocardial protective mechanisms. Ischemic preconditioning (IPC) and postconditioning (I-postC) are endogenous protective mechanisms capable of protecting the myocardium from myocardial infarction, stunning, and ventricular arrhythmia induced by I/R injury. The mechanisms involve induction of triggers, activation of signaling pathways, and end-effectors, which attenuate generation of free radicals and calcium overload induced by I/R. The fact that I-postC can be applied after a prolonged period of ischemia offers a novel approach to myocardial protection. This article mainly reviews the cardioprotection, mechanisms, and application to clinical cardiology of I-postC.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Arritmias Cardíacas
/
Anormalidades Congênitas
/
Traumatismo por Reperfusão Miocárdica
/
Traumatismo por Reperfusão
/
Transdução de Sinais
/
Síndrome de Brugada
/
Pós-Condicionamento Isquêmico
/
Doença do Sistema de Condução Cardíaco
/
Sistema de Condução Cardíaco
/
Infarto do Miocárdio
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2007
Tipo de documento:
Artigo
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