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Biological approaches to generating cardiac biopacemaker for bradycardia / 生理学报
Acta Physiologica Sinica ; (6): 562-570, 2007.
Artigo em Inglês | WPRIM | ID: wpr-258621
ABSTRACT
Normal rhythm in a healthy human heart originates from the natural biological pacemaker, the sinoatrial (SA) node which locates in the right atrium. SA node dysfunction or atrial-ventricular (AV) conduction block causes improper heart rate (bradycardia). Such dysfunction, if severe enough, is currently treated by implanting an electronic pacemaker which has been well established technically, but there are some limitations and inadequacies. Recently, progress in developing engineered cardiac biopacemakers with use of genes or cells has been made in experimental animal models. The hyperpolarization-activated cyclic-nucleotide-modulated (HCN) channel (pacemaker channel) modulates cardiac automaticity via the hyperpolarization-activated cation current (I(f)). HCN genes have been delivered to animal myocardium via viral vectors or HCN-transferred cells for recreating biological pacemakers. Approaches with non-HCN genes or transplantation of beating cells are also novel and have been investigated for generating cardiac biopacers. This article summarizes the progresses in research on recreation of cardiac biopacemakers. Genetically engineered biological pacemaker holds great promise to potentially cure severe bradycardia if critical issues, such as their stability and longevity, are properly solved.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Marca-Passo Artificial / Fisiologia / Nó Sinoatrial / Terapêutica / Relógios Biológicos / Bradicardia / Engenharia Genética / Coração / Frequência Cardíaca / Ventrículos do Coração Limite: Humanos Idioma: Inglês Revista: Acta Physiologica Sinica Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Marca-Passo Artificial / Fisiologia / Nó Sinoatrial / Terapêutica / Relógios Biológicos / Bradicardia / Engenharia Genética / Coração / Frequência Cardíaca / Ventrículos do Coração Limite: Humanos Idioma: Inglês Revista: Acta Physiologica Sinica Ano de publicação: 2007 Tipo de documento: Artigo