Effects of Exogenous Carbon Monoxide Releasing Molecules on the Development of Zebrafish Embryos and Larvae / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 453-456, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-258800
ABSTRACT
The use of exogenous carbon monoxide releasing molecules (CORMs) provides promise for clinical application; however, the hazard potential of CORMs in vivo remains poorly understood. The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to 400 μmol/L during 4-144 h post fertilization. Toxicity endpoints of mortality, spontaneous movement, heart rate, hatching rate, malformation, body length, and larval behavior were measured. CORM-3 disrupted the progression of zebrafish larval development at concentrations exceeding 50 μmol/L, resulting in embryonic developmental toxicity.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Compostos Organometálicos
/
Farmacologia
/
Peixe-Zebra
/
Monóxido de Carbono
/
Cardiotônicos
/
Embriologia
/
Desenvolvimento Embrionário
/
Relação Dose-Resposta a Droga
/
Embrião não Mamífero
/
Toxicidade
Limite:
Animais
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2016
Tipo de documento:
Artigo
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