Prevention of H2O2 Induced Oxidative Damages of Rat Testis by Thymus algeriensis / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 275-285, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-258823
ABSTRACT
<p><b>OBJECTIVE</b>We evaluate the effects of Thymus algeriensis (TEO) against hydrogen peroxide (H2O2) toxicity on body and testis weight, testis sperm count, testis lipid peroxidation, and antioxidant enzyme activities in rats.</p><p><b>METHODS</b>Rats were treated with low (LD) and high dose (HD) of H2O2 (0.1 and 1 mmol/L) in the presence or absence of TEO (150 mg/kg).</p><p><b>RESULTS</b>The results exhibited a significant decrease in body weight and testis weight, in total sperm number decrease (P<0.05), sperm motility and percentage of sperm viability, leading to complete arrest, in sperm flagellar beat frequency by the gavage of 1 mmol/L H2O2 compared to controls. The administration of H2O2 resulted in a significant reduction in testis GSH, GPx, CAT, SOD, and GST activity and significant increase (P<0.05) in MDA concentration compared with the untreated control animals. TEO pre-treatment protected testis from the H2O2 generated oxidative stress. These results were confirmed by histological architecture examinations.</p><p><b>CONCLUSION</b>H2O2 has the ability to alter the sperm function, characteristics and development of testis. However, TEO is an efficient natural agent, which can prevent the testis from H2O2-induced oxidative damage in rats.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Testículo
/
Extratos Vegetais
/
Química
/
Ratos Wistar
/
Estresse Oxidativo
/
Thymus (Planta)
/
Toxicidade
/
Peróxido de Hidrogênio
Limite:
Animais
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2016
Tipo de documento:
Artigo
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