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Maternal Genistein Intake Can Reduce Body Weight in Male Offspring / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 769-772, 2015.
Artigo em Inglês | WPRIM | ID: wpr-258879
ABSTRACT
The study objectives were to investigate the relationship between early exposure to genistein and obesity in young adulthood and to evaluate changes in reproductive health during puberty and adulthood following in utero exposure to genistein. Thirty-two female rats were randomized into four groups; low dose 400 mg genistein/kg diet group (LG), mid-dose 1200 mg genistein/kg diet group (MG), high dose 3600 mg genistein/kg diet group (HG), and control group without genistein diet (CON). Rats were fed genistein at the beginning of pregnancy along with a high-fat diet. Pups were sacrificed at week 4 and week 8 after birth. High performance liquid chromatography (HPLC) results showed a correlation between maternal genistein intake and genistein concentration in pups' plasma. Compared to CON, body weight reduced significantly in male HG group at week 8. No statistical differences were found in plasma estradiol (E2), testosterone (T), interleukin (IL)-6, and C-reactive protein (CRP) levels with early genistein exposure. Furthermore, uterine histopathology showed notable changes in groups HG and MG compared with CON at week 4 and week 8. In conclusion, maternal genistein supplement could reduce body weight in male pups and alter uterine histopathology in female pups.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Efeitos Tardios da Exposição Pré-Natal / Útero / Sangue / Peso Corporal / Gorduras na Dieta / Distribuição Aleatória / Genisteína / Fenômenos Fisiológicos da Nutrição Materna / Fenômenos Fisiológicos da Nutrição Animal Limite: Animais / Gravidez Idioma: Inglês Revista: Biomedical and Environmental Sciences Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Efeitos Tardios da Exposição Pré-Natal / Útero / Sangue / Peso Corporal / Gorduras na Dieta / Distribuição Aleatória / Genisteína / Fenômenos Fisiológicos da Nutrição Materna / Fenômenos Fisiológicos da Nutrição Animal Limite: Animais / Gravidez Idioma: Inglês Revista: Biomedical and Environmental Sciences Ano de publicação: 2015 Tipo de documento: Artigo