Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) Activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian Individuals / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 660-665, 2015.
Article
em En
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| ID: wpr-258894
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Nephrolithiasis is one of the most common disorders of the urinary tract. The aim of this study was to examine a possible relationship between DNase I/II activity and E3 SUMO-protein ligase NSE2 in the sera of nephrolithiasis patients to evaluate the possibility of a new biomarker for evaluating kidney damage.</p><p><b>METHODS</b>Sixty nephrolithiasis patients and 50 control patients were enrolled in a case-control study. Their blood urea, creatinine, protein levels and DNase I/II activity levels were measured by spectrometry. Serum NSMCE2 levels were measured by ELISA. Blood was collected from patients of the government health clinics in Kuantan-Pahang and fulfilled the inclusion criteria.</p><p><b>RESULTS</b>The result indicated that mean levels of sera NSMCE2 have a significantly increase (P<0.01) in patients compared to control group. Compared with control subjects, activities and specific activities of serum DNase I and II were significantly elevated in nephrolithiasis patients (P$lt;0.01).</p><p><b>CONCLUSION</b>This study suggests that an increase in serum concentrations of DNase I/II and E3 SUMO-protein ligase NSE2 level can be used as indicators for the diagnosis of kidney injury in patients with nephrolithiasis.</p>
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Assunto principal:
Ureia
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Sangue
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Hemoglobinas
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Proteínas Sanguíneas
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Estudos de Casos e Controles
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Creatinina
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Desoxirribonuclease I
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Endodesoxirribonucleases
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Nefrolitíase
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Ligases
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2015
Tipo de documento:
Article