Anti-inflammatory and analgesic potency of carboxyamidotriazole, a tumoristatic agent / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 315-321, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-259021
ABSTRACT
<p><b>OBJECTIVE</b>To explore the potential anti-inflammatory and analgesic activities of carboxyamidotriazole (CAI).</p><p><b>METHODS</b>A variety of animal models, including the croton oil-induced ear edema, the cotton-induced granuloma, the rat adjuvant-induced arthritis, were used to evaluate anti-inflammatory effect of CAI. Vascular endothelial growth factor (VEGF)--or histamine-stimulated local vascular permeability in mouse modulated by CAI was also determined. In addition, we assessed the effect of CAI on the levels of proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-beta) at the site of inflammation and in sera. Moreover, antinociceptive effect of CAI on inflammatory pain was assessed using acetic acid-induced writhing model and the formalin test.</p><p><b>RESULTS</b>CAI significantly inhibited acute and chronic phases of inflammation, reduced VEGF or histamine-induced vascular permeability, and showed marked inhibition of proinflammatory cytokines such as TNF-alpha and IL-1 beta. CAI also showed potential therapeutic effect on peripheral inflammatory pain.</p><p><b>CONCLUSION</b>CAI is a promising anti-inflammatory and analgesic agent.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Triazóis
/
Ratos Wistar
/
Avaliação Pré-Clínica de Medicamentos
/
Analgésicos
/
Camundongos Endogâmicos ICR
/
Anti-Inflamatórios
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2009
Tipo de documento:
Artigo
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