Pathogenesis of post-transplantation diabetes mellitus in 40 renal transplantation recipients / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 292-295, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-259025
ABSTRACT
<p><b>OBJECTIVE</b>To explore pathogenesis of post-transplantation diabetes mellitus (PTDM) in renal transplantation recipients.</p><p><b>METHODS</b>A total of 40 renal transplantation recipients were divided into three groups based on oral glucose tolerance test results:
normal glucose tolerance (NGT) group (n = 10), impaired fasting glycaemia + impaired glucose tolerance (IFG + IGT) group (n = 16), and PTDM group (n = 14). Insulin resistance (IR) and beta cell function were assessed by homeostasis model.</p><p><b>RESULTS</b>The differences of the immunosuppressive agents used in these groups were not statistically significant (P > 0.05). Compared with NGT group, insulin area under curve and homeostasis model assessment-insulin resistance index were significantly higher in IGT + IFG group and PTDM group (P < 0.05). Compared with NGT group and IGT + IPG group, insulin secretion index at 30 min and homeostasis model assessment-insulin secretion index were significantly lower in PTDM group (P < 0.05).</p><p><b>CONCLUSION</b>Insulin resistance and beta-cell dysfunction may play a key role in the pathogenesis of PTDM.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Complicações Pós-Operatórias
/
Resistência à Insulina
/
Estudos Retrospectivos
/
Transplante de Rim
/
Diabetes Mellitus
/
Células Secretoras de Insulina
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2009
Tipo de documento:
Artigo
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