Mismatch repair gene hMLH1 A655G/A polymorphism and colorectal cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 216-218, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-259305
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the etiological role of hMLH1 gene A655 polymorphism in colorectal cancer.</p><p><b>METHODS</b>A case-control study was carried out, including 115 colorectal cancer patients and 135 healthy people as control. Genomic DNA was extracted from peripheral white blood cell from all the subjects. Polymorphism was detected by PCR-based DHPLC analysis and verified by DNA sequencing.</p><p><b>RESULTS</b>The hMLH1 gene A655G polymorphism was detected in 3.0% of healthy people and 11.3% of colorectal cancer patients (P<0.01), and the difference was significant (P<0.01). The hMLH1 gene A655G polymorphism was detected in 8.2% of tubular adenocarcinoma or tubular-papillary adenocarcinoma and 27.8% of mucinous adenocarcinoma, which was also significant (P<0.05).Meanwhile, hMLH1 gene A655G polymorphism was not associated with age, gender and lymphatic metastasis (all P>0.05).</p><p><b>CONCLUSIONS</b>The hMLH1 gene A655G polymorphism may play a role in the pathogenesis of colorectal cancer. Determination of the polymorphism may be a potential marker to predict the prognosis of colorectal cancer patients.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Proteínas Nucleares
/
Neoplasias Colorretais
/
Estudos de Casos e Controles
/
Análise de Sequência de DNA
/
Polimorfismo de Nucleotídeo Único
/
Proteínas Adaptadoras de Transdução de Sinal
/
Reparo de Erro de Pareamento de DNA
/
Proteína 1 Homóloga a MutL
/
Genética
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Gastrointestinal Surgery
Ano de publicação:
2010
Tipo de documento:
Artigo
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