Maintenance effect of polyglycosides of Tripterygium wilfordii on remission in postoperative Crohn disease / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 491-493, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-259382
ABSTRACT
<p><b>OBJECTIVE</b>To observe the maintenance effect of polyglycosides of Tripterygium wilfordii (GTW) on remission in postoperative Crohn disease (CD).</p><p><b>METHODS</b>From 2005 to 2007, 45 adult cases of postoperative Crohn disease were randomly divided into two groups, GTW group and mesalazine group, which received GTW and mesalazine treatment respectively. CD activity index (CDAI) and clinical markers were collected at 0, 3, 6, 12 months or at the onset of symptoms. Ileocolonoscopy was performed at the end of the trial (1 year after operation) or at the onset of symptoms, and recurrence score were recorded.</p><p><b>RESULTS</b>No clinical recurrence was ascertained in both groups at 3 months. Four patients (18.2%) in GTW group relapsed and 5 (21.7%) in mesalazine group relapsed at 6 months (P=0.530). Seven patients (31.8%) in GTW group and 9 (39.1%) in mesalazine group relapsed at one year (P=0.421). Ten patients (45.5%) in GTW group had endoscopic recurrence compared with 14 (60.9%) in mesalazine group at one year(P=0.231). There were no significant differences between two groups.</p><p><b>CONCLUSION</b>GTW is similar to mesalazine in maintenance of remission of postoperative Crohn disease.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Período Pós-Operatório
/
Recidiva
/
Doença de Crohn
/
Química
/
Anti-Inflamatórios não Esteroides
/
Resultado do Tratamento
/
Mesalamina
/
Tripterygium
/
Usos Terapêuticos
/
Tratamento Farmacológico
Limite:
Adolescente
/
Adulto
/
Idoso
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Gastrointestinal Surgery
Ano de publicação:
2009
Tipo de documento:
Artigo
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