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Research progress of gene recombinant mesenchymal stem cells as tumor targeting delivery vehicles / 药学学报
Acta Pharmaceutica Sinica ; (12): 1209-1220, 2013.
Artigo em Chinês | WPRIM | ID: wpr-259492
ABSTRACT
The applications of targeting gene delivery systems in tumor therapy have attracted extensive attention of researchers in recent years, as they can selectively deliver the therapeutic gene to tumor sites, improve the success rate of gene therapy and reduce the side effects. Therefore, design and development of novel gene delivery vehicles have been a hot area of current research. Recent studies have shown that mesenchymal stem cells (MSCs) have the ability to migrate towards and engraft into the tumor sites. Therefore, these properties make them a great hope for efficient targeted-delivery vehicles in cancer gene therapy. In this review, we examine the promising of utilization of MSCs as a targeted-delivery vehicle for cancer gene therapy, and summarize various challenges and concerns regarding this therapy.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Terapêutica / Proteínas Recombinantes / Portadores de Fármacos / Transfecção / Terapia Genética / Movimento Celular / Técnicas de Transferência de Genes / Marcação de Genes / Biologia Celular Limite: Animais / Humanos Idioma: Chinês Revista: Acta Pharmaceutica Sinica Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fisiologia / Terapêutica / Proteínas Recombinantes / Portadores de Fármacos / Transfecção / Terapia Genética / Movimento Celular / Técnicas de Transferência de Genes / Marcação de Genes / Biologia Celular Limite: Animais / Humanos Idioma: Chinês Revista: Acta Pharmaceutica Sinica Ano de publicação: 2013 Tipo de documento: Artigo