Design, synthesis and antitumor activity of valproic acid salicylanilide esters / 药学学报
Acta Pharmaceutica Sinica
;
(12): 874-880, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-259537
ABSTRACT
A series of valproic acid salicylanilide esters were designed and synthesized based on the principle of prodrug. The structures of the target compounds were confirmed by MS, 1H NMR and 13C NMR. Anti-tumor activities of these compounds against K562, A549, A431 cells in vitro were investigated by MTT assay and SRB assay. The results indicated that the compounds 6h-6j were found to have stronger cell growth inhibitory action than gefitinib, and comparable to niclosamide, which are worth to be intensively studied further.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Salicilanilidas
/
Relação Estrutura-Atividade
/
Pró-Fármacos
/
Desenho de Fármacos
/
Estrutura Molecular
/
Química
/
Ácido Valproico
/
Células K562
/
Concentração Inibidora 50
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2013
Tipo de documento:
Artigo
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