The associations between idiosyncratic adverse drug reactions and HLA alleles and their underlying mechanism / 药学学报
Acta Pharmaceutica Sinica
;
(12): 799-808, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-259547
ABSTRACT
With the advent of Twenty-First century, more and more genome-wide association studies (GWAS) showed that idiosyncratic adverse drug reactions (ADRs) were closely related with human leukocyte antigen (HLA) alleles, such as the associations of abacavir-HLA-B*5701, allopurinol-HLA-B*5801, and carbamazepine-HLA-B*1502, etc. To explore the mechanisms of these idiosyncratic drug reactions, hapten hypothesis, danger signal hypothesis, pharmacological interaction (P-I) concept and autoimmune mechanism are proposed. In this paper, recent GWAS studies on the HLA-mediated adverse drug reactions and underlying mechanism are reviewed in detail.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Carbamazepina
/
Didesoxinucleosídeos
/
Antígenos HLA-B
/
Alopurinol
/
Síndrome de Stevens-Johnson
/
Fármacos Anti-HIV
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Alelos
/
Inibidores Enzimáticos
/
Alergia e Imunologia
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2013
Tipo de documento:
Artigo
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