Correlation between the Expression of microRNA 451 in Red Blood Cells and Chronic Mountain Sickness / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 481-484, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-259561
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between the expression of microRNA-451 in red blood cells and chronic mountain sickness(CMS).</p><p><b>METHODS</b>Peripheral blood samples were collected from emigrant CMS patients (28 cases), localized CMS patients (12 case), emigrant healthy people (24 case) and localized healthy people (22 case). The microRNA-451 expression in red blood cells was measured by the RT-PCR. The results combined with the clinical data of patients were analysed.</p><p><b>RESULTS</b>The expression of microRNA-451 in emigrant CMS patients was higher than that in emigrant healthy people (P<0.05); the expression of microRNA-451 in localized CMS patients was higher than that in localized healthy people (P<0.05); the microRNA-451 expression had no statistical difference between emargant and localized healthy people. The level of hemoglobin in CMS patients was positively correlated with the expression of microRNA-451 in red cells (r=0.701).</p><p><b>CONCLUSION</b>There is a certain level of microRNA-451 in healthy people, the expression of microRNA-451 in CMS patients is significantly higher than that in healthy people. MicroRNA-451 may play an important role in the process of chronic mountain sickness.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Hemoglobinas
/
Doença Crônica
/
MicroRNAs
/
Eritrócitos
/
Doença da Altitude
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2015
Tipo de documento:
Artigo
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