Research progress of myeloproliferative neoplasms / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 278-284, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-259599
ABSTRACT
The classic BCR-ABL negative myeloproliferative neoplasm (MPN) comprise polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). These three disorders are characterized by stem cell-derived clonal myeloproliferation and presence of somatic mutations. The WHO diagnostic criteria for the classic BCR-ABL negative MPN has been revised in the 2008 edition by incorporating new information about their molecular pathogenesis. Robust prognostic system for PMF has already done, and those for PV and ET are under discussion. Treatment with novel drugs is promising, and allo-stem cell transplantation (allo-ASCT) is the only curative treatment for myelofibrosis, however, the patient selection and management before transplant have been discussed for a long time.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Policitemia Vera
/
Prognóstico
/
Organização Mundial da Saúde
/
Proteínas de Fusão bcr-abl
/
Mielofibrose Primária
/
Trombocitemia Essencial
/
Transtornos Mieloproliferativos
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2015
Tipo de documento:
Artigo
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