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Mechanism of macrophage polarization on spinal cord injury / 中国骨伤
Article em Zh | WPRIM | ID: wpr-259782
Biblioteca responsável: WPRO
ABSTRACT
Spinal cord injury is a serious trauma of the spinal and nervous system, local tissue destruction and microcirculation disturbance can lead to a more serious spinal cord injury and extensive necrosis of neurons. Spinal cord injury often accompany with Inflammation reaction producing a variety of cytokines and bioactive substances, result in macrophage polarization. M1 macrophages polarization are induced by IFN-γ, LPS, TNF-α and so on, it show the damage and proinflammatory effect. M2 macrophages polarization are caused by IL-4, IL-10, IL-13 and show the recovery and anti-inflammatory effect. However, clinical treatment after spinal cord injury is very limited, inhibition of proinflammatory and promotion of anti-inflammatory by regulating the M1 macrophages and M2 macrophages is a new direction for the treatment of spinal cord injury. The article will review different phenotype and function of macrophages after spinal cord injury.
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Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: China Journal of Orthopaedics and Traumatology Ano de publicação: 2018 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: China Journal of Orthopaedics and Traumatology Ano de publicação: 2018 Tipo de documento: Article