Role of PXR and CAR in Cholestasis / 대한간학회지
The Korean Journal of Hepatology
;
: 5-15, 2006.
Artigo
em Coreano
| WPRIM
| ID: wpr-25994
ABSTRACT
Cholestatic liver diseases are characterized by impairments of bile flows and accumulations of biliary constituents such as bile acids and bilirubin. The changes of phase I and II metabolism and the hepatobiliary transport system minimize cholestatic liver injury. These adaptive responses are transcriptionally regulated by several nuclear receptors. Recent studies have revealed that the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are key nuclear receptors for regulating many of the adaptive responses noted in cholestasis. PXR and CAR coordinately regulate not only bile acid metabolism and transport, but also bilirubin clearance. PXR and CAR ligands may be useful in the future for the treatment of cholestatic liver disease.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fatores de Transcrição
/
Receptores de Esteroides
/
Colestase
/
Receptores Citoplasmáticos e Nucleares
Limite:
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Hepatology
Ano de publicação:
2006
Tipo de documento:
Artigo
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