A study on the relationship between interleukin-10 promoter polymorphism and autoimmune liver disease / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 356-358, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-259994
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether three biallelic polymorphisms at the position -592, -819 and -1082 in the promoter region of the IL-10 gene were associated with the incidence of autoimmune liver disease.</p><p><b>METHODS</b>The IL-10 -592 and IL-10-1082 polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphisms analysis (PCR-RFLP), while polymerase chain reaction- sequence specific primer (PCR-SSP) assay was used to detect IL-10 -819 polymorphisms.</p><p><b>RESULTS</b>Among 54 Chinese patients with AIH or 77 Chinese patients with PBC versus healthy controls, the frequency of AA, GA genotypes at IL-10 gene promoter -1082 position was 87.0% or 83.1% versus 90.0%, 13.0% or 16.9% versus 10.0%, respectively (P > 0.05), the GG genotype in Chinese populations is absent; the frequency of CC, CT, TT genotypes at IL-10 gene promoter -819 position was 11.11% or 9.1% versus 8.1%, 44.4% or 53.3% versus 45.0%, 44.4% or 37.7% versus 46.9%, respectively (P > 0.05); the frequency of CC, CA, AA genotypes at IL-10 gene promoter -592 position was 4.9% or 14.3% versus 10.0%, 51.2% or 53.3% versus 51.9%, 43.9% or 32.5% versus 38.1%, respectively (P > 0.05). No alleles differed significantly in each groups.</p><p><b>CONCLUSION</b>There were no association between IL-10 gene polymorphisms and autoimmune liver disease</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo de Fragmento de Restrição
/
Reação em Cadeia da Polimerase
/
Regiões Promotoras Genéticas
/
Interleucina-10
/
Hepatite Autoimune
/
Alergia e Imunologia
/
Genética
/
Cirrose Hepática Biliar
/
Métodos
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2004
Tipo de documento:
Artigo
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