Study of the correlation between drug exposure and blood concentration during cyclosporine microemulsion absorption phase in Chinese adult liver transplant recipients / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 328-330, 2004.
Artigo
em Chinês
| WPRIM
| ID: wpr-260005
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the correlation between drug exposure (AUC0-4) and blood concentration of different sample points during Neoral absorption phase in Chinese adult liver transplant recipients, and to evaluate the possibility of using post-dose 2 hour level (C2) as a surrogate marker of AUC0-4 for the therapeutic drug monitoring (TDM) of Neoral.</p><p><b>METHODS</b>Neoral levels at 0, 1, 2, 3, and 4 hours (C1, C2, C3, C4) after morning dose of 22 de novo Chinese adult liver transplant recipients were monitored during different posttransplant periods. Liner regression was used to analyze the correlation between CsA concentration at different time points and the AUC0-4.</p><p><b>RESULTS</b>The best correlation was found at C2, while the correlation of C0 was the lowest. During following-up, the correlation between C2 and AUC0-4 was very stable.</p><p><b>CONCLUSION</b>C2 had the best correlation with drug exposure. This correlation is very stable. C2 may be used as a good surrogate marker of AUC0-4 for the TDM of Neoral.</p>
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Período Pós-Operatório
/
Sangue
/
Farmacocinética
/
Monitorização Imunológica
/
Transplante de Fígado
/
Monitoramento de Medicamentos
/
Ciclosporina
/
Área Sob a Curva
/
Povo Asiático
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2004
Tipo de documento:
Artigo
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